Krzysztof Marycz Selected Research

Metabolic Syndrome (Dysmetabolic Syndrome X)

11/2023	Sex hormone-binding globulin (SHBG) mitigates ER stress and improves viability and insulin sensitivity in adipose-derived mesenchymal stem cells (ASC) of equine metabolic syndrome (EMS)-affected horses.
10/2023	Sex Hormone-Binding Globulin (SHBG) Maintains Proper Equine Adipose-Derived Stromal Cells (ASCs)' Metabolic Functions and Negatively Regulates their Basal Adipogenic Potential.
1/2023	Sex hormone-binding globulin improves lipid metabolism and reduces inflammation in subcutaneous adipose tissue of metabolic syndrome-affected horses.
1/2023	The PTP1B inhibitor MSI-1436 ameliorates liver insulin sensitivity by modulating autophagy, ER stress and systemic inflammation in Equine metabolic syndrome affected horses.
1/2023	The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity.
9/2022	Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment.
1/2022	The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome - Novel Concept and Therapeutic Implications.
1/2022	Astaxanthin Carotenoid Modulates Oxidative Stress in Adipose-Derived Stromal Cells Isolated from Equine Metabolic Syndrome Affected Horses by Targeting Mitochondrial Biogenesis.
1/2021	Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes In Vitro and Ex Vivo.
1/2021	MSI-1436 improves EMS adipose derived progenitor stem cells in the course of adipogenic differentiation through modulation of ER stress, apoptosis, and oxidative stress.

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Krzysztof Marycz Research Topics

Disease

24	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2023 - 01/2015
20	Insulin Resistance 01/2024 - 01/2018
14	Inflammation (Inflammations) 01/2024 - 01/2017
9	Obesity 01/2024 - 01/2015
6	Hyperinsulinism (Hyperinsulinemia) 05/2023 - 01/2018
5	Hyperglycemia 05/2023 - 01/2021
5	Osteoporosis 01/2023 - 01/2021
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2023 - 05/2020
4	Type 2 Diabetes Mellitus (MODY) 11/2018 - 01/2017
3	Neoplasms (Cancer) 08/2019 - 01/2015
2	Bone Fractures (Bone Fracture) 03/2022 - 11/2019
2	Wounds and Injuries (Trauma) 01/2021 - 01/2017
2	Osteosarcoma (Osteogenic Sarcoma) 12/2020 - 11/2019
2	Osteochondritis Dissecans 01/2020 - 01/2019
2	Retinal Degeneration 04/2019 - 10/2017
1	Keratitis 03/2023
1	Fibrosis (Cirrhosis) 01/2023
1	Graft vs Host Disease (Graft-Versus-Host Disease) 10/2022
1	Atopic Dermatitis (Atopic Eczema) 10/2022
1	Uveitis 10/2022
1	Rheumatoid Arthritis 10/2022
1	Psoriasis (Pustulosis Palmaris et Plantaris) 10/2022
1	Mastocytoma 02/2022
1	Metabolic Diseases (Metabolic Disease) 01/2022
1	Bone Cysts (Bone Cyst) 12/2020
1	Pain (Aches) 11/2020
1	Dentin Sensitivity 11/2020
1	Animal Diseases 09/2020
1	Adenocarcinoma of Lung 06/2020
1	Prediabetic State (Prediabetes) 06/2020
1	Neoplasm Metastasis (Metastasis) 06/2020
1	Bone Diseases (Bone Disease) 01/2020
1	Osteoarthritis 01/2020
1	Osteomyelitis 01/2020
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2020
1	Tendinopathy (Tendonitis) 01/2020

Drug/Important Bio-Agent (IBA)

11	Insulin (Novolin)FDA Link 01/2024 - 01/2018
7	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 05/2019
5	IonsIBA 01/2024 - 12/2017
4	Sex Hormone-Binding GlobulinIBA 11/2023 - 01/2021
4	Metformin (Glucophage)FDA LinkGeneric 01/2019 - 01/2015
3	Sirtuin 1IBA 01/2024 - 05/2019
3	Triglycerides (Triacylglycerol)IBA 01/2024 - 01/2018
3	CytokinesIBA 10/2023 - 01/2018
3	AlkaloidsIBA 01/2023 - 01/2019
3	Protein Tyrosine PhosphatasesIBA 01/2023 - 01/2023
3	N-hydroxy-2-aminopyreneIBA 03/2022 - 11/2019
3	ResveratrolIBA 12/2019 - 10/2018
3	LipidsIBA 11/2019 - 11/2017
2	Proteins (Proteins, Gene)FDA Link 10/2023 - 11/2019
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 03/2023 - 10/2022
2	NF-kappa B (NF-kB)IBA 01/2023 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 09/2022 - 06/2020
2	manganese ferriteIBA 06/2022 - 12/2020
2	astaxanthine (astaxanthin)IBA 01/2022 - 09/2020
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 03/2019
2	AlginatesIBA 12/2020 - 11/2017
2	MicroRNAs (MicroRNA)IBA 06/2020 - 05/2019
2	Nonesterified Fatty Acids (NEFA)IBA 05/2020 - 11/2019
2	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2020 - 11/2019
2	Retinaldehyde (Retinal)IBA 04/2019 - 10/2017
2	Therapeutic UsesIBA 06/2018 - 03/2017
2	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2017 - 01/2017
2	Biocompatible Materials (Biomaterials)IBA 01/2017 - 07/2013
1	2- (N- (7- nitrobenz- 2- oxa- 1,3- diazol- 4- yl)amino)- 2- deoxyglucoseIBA 01/2024
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2024
1	TunicamycinIBA 01/2023
1	EnzymesIBA 01/2023
1	Serum Amyloid A Protein (Serum Amyloid A)IBA 01/2023
1	24-dihydroxy-5-cholestane 24-sulfate 3-N-1(spermine)-7IBA 01/2023
1	Fibrinogen (Factor I)FDA Link 01/2023
1	ElementsIBA 01/2023
1	AdiponectinIBA 01/2023
1	Immunosuppressive Agents (Immunosuppressants)IBA 10/2022
1	amino-propyl-triethoxysilaneIBA 03/2022
1	ferric oxide (iron oxide)IBA 03/2022
1	resazurinIBA 02/2022
1	AdipokinesIBA 01/2022
1	Carotenoids (Carotene)IBA 01/2022
1	Polymethyl Methacrylate (Sol)IBA 09/2021
1	Blood Proteins (Serum Proteins)IBA 01/2021
1	FatsIBA 01/2021
1	LeptinIBA 01/2021
1	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 01/2021
1	Plant ExtractsIBA 01/2021
1	HydrogelsIBA 12/2020
1	Durapatite (Hydroxylapatite)IBA 11/2020
1	Insulin ReceptorIBA 01/2020
1	LipopolysaccharidesIBA 01/2020
1	bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA 01/2020
1	Azacitidine (5 Azacytidine)FDA Link 12/2019
1	Cartilage Oligomeric Matrix ProteinIBA 12/2019
1	Collagen Type II (Type II Collagen)IBA 12/2019
1	Aggrecans (Aggrecan)IBA 12/2019
1	Messenger RNA (mRNA)IBA 12/2019

Therapy/Procedure

11	Therapeutics 01/2023 - 01/2010
3	Drug Therapy (Chemotherapy) 05/2023 - 11/2019
2	Transplantation 01/2018 - 10/2017
1	Intra-Articular Injections 01/2023
1	Rejuvenation 01/2023